Journal
TUBERCULOSIS
Volume 92, Issue 1, Pages 72-83Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2011.05.005
Keywords
TAACF; Antitubercular; High throughput screening methods; Medicinal chemistry analysis; Designed kinase inhibitor library
Categories
Funding
- [N01-AI-95364]
- [N01-AI-15449]
Ask authors/readers for more resources
Kinase targets are being pursued in a variety of diseases beyond cancer, including immune and metabolic as well as viral, parasitic, fungal and bacterial. In particular, there is a relatively recent interest in kinase and ATP-binding targets in Mycobacterium tuberculosis in order to identify inhibitors and potential drugs for essential proteins that are not targeted by current drug regimens. Herein, we report the high throughput screening results for a targeted library of approximately 26,000 compounds that was designed based on current kinase inhibitor scaffolds and known kinase binding sites. The phenotypic data presented herein may form the basis for selecting scaffolds/compounds for further enzymatic screens against specific kinase or other ATP-binding targets in Mycobacterium tuberculosis based on the apparent activity against the whole bacteria in vitro. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available