Journal
TUBERCULOSIS
Volume 91, Issue 3, Pages 187-195Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2011.01.002
Keywords
Tuberculosis; Mycobacteria; Lipid; Immunity
Categories
Funding
- Centre National de la Recherche Scientifique
- European Union
- Agence Nationale de la Recherche
- Fondation pour la Recherche Medicale
- Region Midi-Pyrenees
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The cell envelope of Mycobacterium tuberculosis and other members of the Mycobacterium genus typically contains a broad diversity of unique lipid components. These lipids have been intensively studied for more than 70 years, in terms of their structure, biosynthesis and role in interactions with the host. Several recent excellent reviews provide state-of-the-art knowledge about the structure, biosynthesis and biological activity of mycobacterial lipids.(1-3) We focus here on the most recent findings concerning the supramolecular organisation of the mycobacterial cell envelope, the contribution of lipids to mycobacterial pathogenicity, their mechanisms of action, and their variation in diverse mycobacterial strains. (C) 2011 Elsevier Ltd. All rights reserved.
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