Journal
TUBERCULOSIS
Volume 91, Issue 2, Pages 155-172Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2010.11.009
Keywords
Mycobacterium tuberculosis; Protein structure; X-ray crystallography; Structural genomics; Drug discovery
Categories
Funding
- NIH/NIAID [PO1AIO68135]
- Robert A. Welch Foundation [A-0015]
- NIH
Ask authors/readers for more resources
The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein-protein and protein-ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available