4.5 Article

Photooxidative Amidation of Aldehydes with Amines Catalyzed by Rose Bengal

Journal

ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 4, Issue 6, Pages 533-536

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201500076

Keywords

amidation; artemisinin; oligosaccharides; rose bengal; tertiary amides

Funding

  1. NSFC [2012-21272198]
  2. State Key Laboratory of Chirosciences
  3. Hong Kong Polytechnic University [G-YM50]

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An efficient method for photooxidative amidation of aldehydes with secondary amines has been developed. With the use of a readily available photocatalyst rose bengal, tertiary amides (with examples of oligosaccharides and endoperoxide artemisinin) were obtained in good yields with high chemoselectivity and functional-group compatibility under mild reaction conditions.

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