Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 4, Issue 10, Pages 1020-1024Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201500252
Keywords
asymmetric synthesis; -substituted -amino acids; fluorine; imines; Mannich reaction
Categories
Funding
- National Natural Science Foundation of China [21102071, 21472082]
- Fundamental Research Funds for the Central Universities [020514380018]
Ask authors/readers for more resources
Currently, there is a great demand for the development of new methods for the preparation of fluorine containing compounds. However, biologically relevant molecules bearing fluoroalkyl groups other than CF3 still remain virtually unexplored. Herein, we report a simple approach for preparation of -amino acids derivatives containing CHF2, CBrF2, and CClF2 groups via addition reactions of the corresponding (Ss)-N-(tert-butanesulfinyl)-CXF2-acetaldimines and alkyl-acetate-derived enolates. The reactions occur with excellent diastereoselectivity of up to >99:1 providing a simple and reliable access to a type of biologically valuable derivatives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available