Silver-Nitrite-Assisted In Situ Diazotization Reaction: Cross-Coupling of Anilines with Arylboronic Acids at Room Temperature

A Pd-catalyzed, convenient, and simple one-pot method for the preparation of unsymmetrical biaryls from anilines is established via an insitu diazotization reaction using silver nitrite (AgONO) as an alternative nitrosating reagent. The protocol works under ligand- and base-free conditions at room temperature and tolerates a variety of functionalized anilines and arylboronic acids leading to the corresponding biaryl products in moderate to good yields.