Journal
TROPICAL MEDICINE & INTERNATIONAL HEALTH
Volume 15, Issue 11, Pages 1390-1394Publisher
WILEY
DOI: 10.1111/j.1365-3156.2010.02631.x
Keywords
visceral leishmaniasis; kala-azar; Leishmania donovani; infection markers
Funding
- EU [015374]
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Visceral leishmaniasis (VL) is an important vector-borne disease caused by Leishmania donovani in the Indian subcontinent. The actual incidence and role of asymptomatic infections in the region are not well known. We used the direct agglutination test (DAT) and the rK39 ELISA as L. donovani infection markers in 10 VL endemic villages in Nepal. DAT titre distribution showed two subgroups in the population (infected and non-infected individuals), while rK39 did not. The agreement between both tests was moderate (kappa = 0.53; 95% CI 0.49-0.57). More research is needed to develop validated markers for Leishmania infection.
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