Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 44, Issue 8, Pages 1933-1937Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2015.1111238
Keywords
Bifidobacterium longum; inflammasome; NLRP3; postinfectious irritable bowel syndrome
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We aimed to explore the role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome (PI-IBS). Fifty NIH mice were divided into five groups (n=10). The visceral sensitivities of PI-2W and PI-8W groups significantly exceeded than those of normal control groups (P<0.05), which was significantly decreased in PI-B group (P<0.05). Significantly more IL-18 and IL-1 were expressed in PI-2W and PI-8W groups than those in normal control groups (P<0.05), which was significantly decreased in PI-B group (P<0.05). Bifidobacterium longum may down-regulate IL-18 and IL-1 expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.
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