Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 44, Issue 7, Pages 1774-1782Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2015.1102740
Keywords
Chitosan; doxorubicin HCL; folic acid; imaging; quantum dots; targeting
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We herein first report a method for the synthesis of chitosan (CHI)-folate conjugated colloidal ZnO-Mn+2 quantum dots (QDs) bearing doxorubicin through chemical method (DOX/FA-CHI-QDs) for cancer therapy as well imaging purpose. The entrapment efficiency was determined to be 99.98 +/- 0.012% (DOX/FA-CHI-QDs) and 92.0 +/- 2.62% (DOX-QDs). The developed DOX/FA-CHI-QDs formulations depict the sustained release pattern at the lysosomal pH (pH 5.0). The DOX/FA-CHI-QDs showed enhanced cytotoxicity, cellular uptake and were most preferentially taken up by the cancerous cells via receptor-mediated endocytosis (RME) mechanism. Hence, the QD-based formulation is capable of targeting drug delivery and imaging the delivery process.
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