Journal
AUSTRALIAN DENTAL JOURNAL
Volume 60, Issue 2, Pages 247-254Publisher
WILEY
DOI: 10.1111/adj.12312
Keywords
Antiseptics; chlorhexidine; mouthrinses; Streptococcus mutans
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BackgroundOral antiseptics are valuable in controlling oral infections caused by cariogenic bacteria. The aim of this study was to investigate the effects of mouthrinses and pure antiseptic compounds on Streptococcus mutans and non-mutans bacteria (Streptococcus sanguinis and Lactobacillus acidophilus). MethodsThe agar diffusion assay was employed to determine bacterial growth inhibition. ResultsCommercial mouthrinses containing chlorhexidine gluconate (0.2%), cetylpyridinium chloride (0.05%) and sodium fluoride (0.05%) produced statistically similar growth inhibition of S. mutans, S. sanguinis and L. acidophilus (with zones of inhibition ranging from 7.560.52mm to 7.39 +/- 0.53mm, 17.44 +/- 0.94mm to 18.31 +/- 0.62mm and 8.61 +/- 1.43 to 8.67 +/- 1.43mm respectively, p>0.05). The chlorhexidine mouthwash produced the greatest mean growth inhibition of S. sanguinis and S. mutans compared to all other mouthrinses tested (p<0.01). The minimum concentrations at which inhibition against S. mutans could be detected were chlorhexidine gluconate at 0.005% (wt/vol), cetylpyridinium chloride 0.01% (wt/ vol), povidone iodine 10% (wt/vol) and sodium hypochlorite 0.5% (vol/vol). ConclusionsChlorhexidine (0.01%), cetylpyridinium chloride (0.01%), povidone iodine (10%) and sodium hypochlorite (0.5%) are effective at inhibiting the growth of S. mutans, S. sanguinis and L. acidophilus.
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