Journal
TRENDS IN PLANT SCIENCE
Volume 14, Issue 8, Pages 443-453Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2009.05.004
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Funding
- US National Science Foundation [IBN-0420.152, NSF IOS-0750811]
- Royal Thai Government
- Direct For Biological Sciences [0750811] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems [0750811] Funding Source: National Science Foundation
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mRNA-ribonucleoprotein (mRNP) complexes mediate post-transcriptional control mechanisms in the cell nucleus and cytoplasm. Transcriptional control is paramount to gene expression but is followed by regulated nuclear pre-mRNA maturation and quality control processes that culminate in the export of a functional transcript to the cytoplasm. Once in the cytosol, mRNPs determine the activity of individual mRNAs through regulation of localization, translation, sequestration and turnover. Here, we review how quantitative assessment of mRNAs in distinct cytoplasmic mRNPs, such as polyribosomes (polysomes), has provided new perspectives on post-transcriptional regulation from the global to gene-specific level. In addition, we explore recent genetic and biochemical studies of cytoplasmic mRNPs that have begun to expose RNA-binding proteins in an integrated network that fine-tunes gene expression.
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