Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 35, Issue 9, Pages 479-488Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2014.06.006
Keywords
Epithelial-mesenchymal transition (EMT); cancer, metastasis; invasion; therapy resistance; cancer stem cells; mesenchymal-epithelial transition (MET); therapeutic targets
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Funding
- National Health and Medical Research Council [1022263]
- Queensland Cancer Council [1042819]
- EMPathy National Collaborative Research Program of the National Breast Cancer Foundation, Australia
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The spread of cancer cells to distant organs represents a major clinical challenge in the treatment of cancer. Epithelial mesenchymal transition (EMT) has emerged as a key regulator of metastasis in some cancers by conferring an invasive phenotype. As well as facilitating metastasis, EMT is thought to generate cancer stem cells and contribute to therapy resistance. Therefore, the EMT pathway is of great therapeutic interest in the treatment of cancer and could be targeted either to prevent tumor dissemination in patients at high risk of developing metastatic lesions or to eradicate existing metastatic cancer cells in patients with more advanced disease. In this review, we discuss approaches for the design of EMT-based therapies in cancer, summarize evidence for some of the proposed EMT targets, and review the potential advantages and pitfalls of each approach.
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