Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 35, Issue 10, Pages 510-519Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2014.07.003
Keywords
induced pluripotent stem (iPS) cells; disease modeling; drug discovery; phenotypic screening; high content screening; high throughput RT-PCR; expandable neural progenitors
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Owing to the inherent disconnect between drug pharmacology in heterologous cellular models and drug efficacy in vivo, the quest for more predictive in vitro systems is one of the most urgent challenges of modern drug discovery. An improved pharmacological in vitro profiling would employ primary samples of the proper drug-targeted human tissue or the bona fide human disease-relevant cells. With the advent of induced pluripotent stem (iPS) cell technology the facilitated access to a variety of disease-relevant target cells is now held out in prospect. In this review, we focus on the use of human iPS cell derived neurons for high throughput pharmaceutical drug screening, employing detection technologies that are sufficiently sensitive to measure signaling in cells with physiological target protein expression levels.
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