Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 34, Issue 9, Pages 518-530Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2013.07.003
Keywords
stress hormones; inflammation; nuclear receptor; glucocorticoid-response element
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Funding
- NIEHS Intramural Research Program of the National Institutes of Health
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Glucocorticoids are steroid hormones regulated in a circadian and stress-associated manner to maintain various metabolic and homeostatic functions that are necessary for life. Synthetic glucocorticoids are widely prescribed drugs for many conditions including asthma, chronic obstructive pulmonary disease (COPD), and inflammatory disorders of the eye. Research in the past few years has begun to unravel the profound complexity of glucocorticoid signaling and has contributed remarkably to improved therapeutic strategies. Glucocorticoids signal through the glucocorticoid receptor (GR), a member of the superfamily of nuclear receptors, in both genomic and non-genomic ways in almost every tissue in the human body. In this review, we provide an update on glucocorticoid receptor signaling and highlight the role of GR signaling in physiological and pathophysiological conditions in the major organ systems in the human body.
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