Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 33, Issue 2, Pages 100-108Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2011.10.005
Keywords
-
Categories
Funding
- Dutch Cancer Society [NKI 2007-3764]
Ask authors/readers for more resources
Organic anion-transporting polypeptides (OATPs) are a superfamily of uptake transporters that mediate the cellular uptake of a broad range of endogenous and exogenous compounds. Of these OATP transporters, members of the 1A and 1B subfamilies have broad substrate specificities. Because they are mainly expressed in liver, kidney and small intestine, OATP1A and 1B transporters can have a major impact on the pharmacokinetics of many drugs. To study their role in physiology and drug disposition, several mouse models lacking functional expression of one or more OATPs have been generated. This review discusses recent findings for these models that have led to new insights into the impact of OATP1A and 1B transporters on pharmacokinetics and toxicokinetics, and on bilirubin detoxification and bile acid handling in normal liver physiology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available