Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 31, Issue 1, Pages 46-51Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2009.10.004
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Funding
- National Cancer Institute (NCI) [P01 CA089392]
- National Institute on Drug Abuse (NIDA) [K02 DA021237]
- NATIONAL CANCER INSTITUTE [P01CA089392] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K02DA021237] Funding Source: NIH RePORTER
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Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha 5-alpha 3-beta 4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha 5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine dependence locus also influences the risk for lung cancer and chronic obstructive pulmonary disease. This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health.
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