Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 30, Issue 4, Pages 212-222Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2008.12.006
Keywords
-
Categories
Funding
- National Institute on Aging [AG026572, P01-AG014751]
- National Institute of Mental Health [1R01 MH67159]
- Bensussen Translational Research Fund
Ask authors/readers for more resources
Controversy regarding estrogen action in the brain remains at the forefront of basic, translational and clinical science for women's health. Here, I provide an integrative analysis of estrogen-inducible plasticity and posit it as a strategy for predicting cognitive domains affected by estrogen in addition to sources of variability. Estrogen enhancement of plasticity is evidenced by increases in neurogenesis, neural network connectivity and synaptic transmission. In parallel, estrogen increases glucose transport, aerobic glycolysis and mitochondrial function to provide the ATP necessary to sustain increased energetic demand. The pattern of plasticity predicts that estrogen would preferentially affect cognitive tasks of greater complexity, temporal demand and associative challenge. Thus, estrogen deprivation should be associated with decrements in these functions. Estrogen regulation of plasticity and bioenergetics provides a framework for predicting estrogen-dependent cognitive functions while also identifying sources of variability and potential biomarkers for identifying women appropriate for hormone therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available