Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 29, Issue 9, Pages 445-453Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2008.06.006
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Funding
- National Institute on Drug Abuse [DA02925]
- Veterans Afrairs VISN 22 Mental Illness Research, Education and Clinical Center
- Swiss National Science Foundation
- Swiss Federal Office of Health (BAG)
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Heffter Research Institute, USA and Zurich
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The history of serotonin research is closely related to the study of hallucinogenic drugs that function as agonists at serotonin-2A receptors. The fundamental idea that psychotic states seen in psychiatric disorders such as schizophrenia might be attributable, in part, to abnormalities in serotonergic systems began with the almost simultaneous discovery of lysergic acid diethylamide (LSD), psilocybin and serotonin. Sixty years of study have confirmed early speculations regarding the important relationship between serotonin and both drug-induced and disorder-based psychotic states. Now, modern biochemical, pharmacological, behavioral, neuroimaging, genetic and molecular biological sciences are converging to understand how serotonergic systems interact with other monoaminergic and glutamatergic systems to modulate states of consciousness and contribute to psychotic disorders such as the group of schizophrenias. This review summarizes experimental assessments of the serotonergic hallucinogen model psychosis in relation to the serotonin hypothesis of schizophrenia.
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