Journal
TRENDS IN PARASITOLOGY
Volume 34, Issue 10, Pages 861-880Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2018.08.007
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Funding
- National Institutes of Health [1R01AI123224, 1R01AI131634-01A1]
- New Jersey Heath Foundation
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Helminth infections represent a significant public health concern resulting in devastating morbidity and economic consequences across the globe. Helminths migrate through mucosal sites causing tissue damage and the induction of type 2 immune responses. Antihelminth protection relies on the mobilization and activation of multiple immune cells, including type 2 innate lymphocytes (ILC2s), basophils, mast cells, macrophages, and hematopoietic stem/progenitor cells. Further, epithelial cells and neurons have been recognized as important regulators of type 2 immunity. Collectively, these pathways stimulate host-protective responses necessary for worm expulsion and the healing of affected tissues. In this review we focus on the innate immune pathways that regulate immunity to helminth parasites and describe how better understanding of these pathways may lead to the development of new therapeutic strategies.
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