Journal
TRENDS IN PARASITOLOGY
Volume 34, Issue 10, Pages 881-890Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2018.07.012
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Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI025038]
- Bill and Melinda Gates Foundation [631, 39129]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [642609]
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Visceral leishmaniasis (VL) is a life-threatening outcome of Leishmania infantum or Leishmania donovani infection. Dogs are the primary domestic reservoir of L. infantum parasites, and ownership of infected dogs increases the risk of human VL. Controlling infection within dog populations is regarded as critical to VL management in endemic countries, both preventing progression of canine disease and limiting parasite transmission to humans and dogs. Here we discuss various strategies that are used to diagnose canine visceral leishmaniasis (CVL) and the possibilities of adapting these for use within population screening and control programs. In addition, given the variable transmissibility of L. infantum to the sand fly vector, we outline some possibilities for the preferential identification of 'super-spreader' dogs among the overall infected population.
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