Journal
TRENDS IN PARASITOLOGY
Volume 30, Issue 3, Pages 141-150Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2013.12.009
Keywords
schistosomiasis; granuloma; immunopathology; chemokine
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Funding
- National Health and Medical Research Council (NHMRC) of Australia
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In hepatic schistosomiasis, pathology arises when schistosome eggs become lodged in the host liver, evoking an interleukin 4 (IL-4)- and IL-13-mediated dominant CD4(+) Th2 immune response. This response leads to the development of granulomas and fibrosis, with eosinophils, neutrophils, macrophages, hepatic stellate cells, and lymphocytes all identified as major cellular contributors to these events. This review outlines the cellular and molecular mechanisms of hepatic schistosomiasis, with an emphasis on the major cellular components and their release of chemokines. The differences between Schistosoma mansoni- and Schistosoma japonicum-induced hepatic granuloma are also discussed. This comprehensive overview of the processes associated with hepatic schistosomiasis may provide new insights into improved treatment for both schistosomiasis and other granulofibrotic diseases.
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