Journal
TRENDS IN PARASITOLOGY
Volume 30, Issue 9, Pages 429-435Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2014.07.002
Keywords
Leishmania; aneuploidy; automixis; chromosome copy-number variation; genetic exchange; sexuality/parasexuality
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Funding
- CNRS
- Ministry of Research
- University Montpellier 1 (Bonus Qualite Recherche)
- Agence Nationale de la Recherche (ANR) within the frame of the 'Investissements d'Avenir' program (PARAFRAP) [ANR-11-LABX-0024-01]
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Reproduction as identical or similar organisms in most biological systems depends on the extreme accuracy of the mitotic (and meiotic) mechanisms involved in the transmission of the genetic material to the two daughter cells. Character recombination and genotype diversification are ensured by the alternation between haploidy and diploidy, which corresponds to the most predominant model in sexually reproducing organisms. In Leishmania, the unique association of high levels of automixis and of constitutive 'mosaic aneuploidy' unexpectedly does not lead to loss of heterozygosity but constitutes an alternative for genotype recombination, hence a source of adaptability.
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