Journal
TRENDS IN PARASITOLOGY
Volume 29, Issue 8, Pages 394-406Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2013.06.005
Keywords
Glossina fuscipes; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; human African trypanosomiasis; sleeping sickness; population genetics; vector control; Uganda
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID) [RO1AI068932]
- Fogarty International Center [D43TW007391, R03TW008755]
- World Health Organization/Tropical Disease Research (WHO/TDR) [A80132]
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Uganda has both forms of human African trypanosomiasis (HAT): the chronic gambiense disease in the northwest and the acute rhodesiense disease in the south. The recent spread of rhodesiense into central Uganda has raised concerns given the different control strategies the two diseases require. We present knowledge on the population genetics of the major vector species Glossina fuscipes fuscipes in Uganda with a focus on population structure, measures of gene flow between populations, and the occurrence of polyandry. The microbiome composition and diversity is discussed, focusing on their potential role on trypanosome infection outcomes. We discuss the implications of these findings for large-scale tsetse control programs, including suppression or eradication, being undertaken in Uganda, and potential future genetic applications.
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