Journal
TRENDS IN PARASITOLOGY
Volume 28, Issue 12, Pages 546-554Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2012.08.008
Keywords
Apicomplexa; Plasmodium; Toxoplasma; cell biology; subcellular localization; organelles; microscopy; GFP; antibody
Categories
Funding
- Australian Research Council [FT0990350]
- Melbourne Research Scholarship
- Australian Research Council [FT0990350] Funding Source: Australian Research Council
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Parasites from the phylum Apicomplexa include causative agents of serious diseases including malaria (Plasmodium spp.) and toxoplasmosis (Toxoplasma gondii). Apicomplexan parasites infect thousands of types of animal cells and send their proteins to an array of compartments within their own cell, as well as exporting proteins into and beyond their host cell. Ascertaining destinations to which individual proteins are delivered allows researchers to better understand parasite biology and to identify potential targets for therapeutic interventions. Our toolkit for establishing subcellular locations of apicomplexan proteins is becoming more extensive and specialized, and here we review developments in this technology.
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