Journal
TRENDS IN PARASITOLOGY
Volume 27, Issue 11, Pages 505-513Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2011.07.004
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Funding
- Biotechnology and Biological Sciences Research Council, Merial Limited
- Department of Education and Learning for Northern Ireland
- Department of Agriculture and Rural Development for Northern Ireland
- Biotechnology and Biological Sciences Research Council [BB/H019472/1] Funding Source: researchfish
- BBSRC [BB/H019472/1] Funding Source: UKRI
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RNA interference (RNAi) has revolutionised approaches to gene function determination. From a parasitology perspective, gene function studies have the added dimension of providing validation data, increasingly deemed essential to the initial phases of drug target selection, pre-screen development. Notionally advantageous to those working on nematode parasites is the fact that Caenorhabditis elegans research spawned RNAi discovery and continues to seed our understanding of its fundamentals. Unfortunately, RNAi data for nematode parasites illustrate variable and inconsistent susceptibilities which undermine confidence and exploitation. Now well-ensconced in an era of nematode parasite genomics, we can begin to unscramble this variation.
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