Journal
TRENDS IN PARASITOLOGY
Volume 26, Issue 5, Pages 230-235Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2010.02.002
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Funding
- Bill and Melinda Gates foundation [47029]
- Seventh Framework Programme [201222]
- Danish Council for Independent Research/Medical Sciences (FSS) [271-07-0696]
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Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) accumulating in the placenta and has dire consequences for both mother and child. The multi-domain antigen VAR2CSA confers specific adhesion of IEs to chondroitin sulphate A (CSA) in the placenta, and is the leading PAM vaccine candidate. Recent data from different laboratories show that the binding properties of individual VAR2CSA domains do not reflect the native CSA-specific adhesion of IEs, which questions the relevance of the information obtained from single domain binding assays and co-crystallization experiments. Here, we discuss the implications of these findings for VAR2CSA vaccine development and highlight the need for studying the native structure of this protein.
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