Journal
TRENDS IN PARASITOLOGY
Volume 24, Issue 8, Pages 364-370Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2008.05.002
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Funding
- National Institutes of Health
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The idea of malaria transmission-blocking vaccines (TBVs) surfaced more than two decades ago. Since then, the research paradigm focused on developing TBVs that target surface antigens of parasite sexual stages. Only recently has an effort emerged that flipped this paradigm, targeting antigens of the parasite's obligate invertebrate vector, the Anopheles mosquito. Here, we review the current state of knowledge of mosquito-based TBVs and discuss the utility of this approach for future vaccine development.
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