Journal
TRENDS IN PARASITOLOGY
Volume 24, Issue 5, Pages 199-200Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2008.02.003
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The mechanism by which the host develops protective immunity to malaria remains poorly understood. Dendritic cells (DCs) are central to the initiation and regulation of the adaptive immune response. Modulation of DC function might enable Plasmodium to evade the immune system. Millington et al. propose one mechanism by which malaria inhibits DC-T-cell interactions without interfering directly with T-cell receptor engagement. The consequence is a decrease in the co-stimulation required to develop an effective immune response.
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