Journal
TRENDS IN NEUROSCIENCES
Volume 37, Issue 3, Pages 125-135Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.12.001
Keywords
clinical translation; species differences; neuroimmunology; neuroinflammation; primary cell culture
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Funding
- Health Research Council of New Zealand
- Hugh Green Foundation
- Lynette Sullivan Trust
- Coker Trust
- Gravida-National Centre for Growth and Development
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Despite increasing evidence of major differences between rodent and human immune and neurological function, relatively few biomedical studies are performed with human cells. This review takes the example of neuroimmunology research and the microglia cell type to illustrate the emerging differences between rodent and human research findings. Microglia are involved in disease states and normal aging processes of the adult human brain. Although rodent microglia are often used in studies investigating microglial function, there are important differences between rodent microglia and their human counterparts. To maximise the relevance of our basic research to the clinical setting, it is necessary to integrate more human-based research into current biomedical research practise and we discuss practical steps towards this aim.
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