Journal
TRENDS IN NEUROSCIENCES
Volume 36, Issue 3, Pages 174-184Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2012.11.008
Keywords
glia; epilepsy; neuroinflammation; astrocyte; microglia
Categories
Funding
- NINDS NIH HHS [NS079202, NS072094, NS077582] Funding Source: Medline
Ask authors/readers for more resources
Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and hypersynchrony of brain neurons. Current theories of pathophysiology stress neuronal dysfunction and damage, and aberrant connections as relevant factors. Most antiepileptic drugs target neuronal mechanisms. However, nearly one-third of patients have seizures that are refractory to available medications; a deeper understanding of mechanisms may be required to conceive more effective therapies. Recent studies point to a significant contribution by non-neuronal cells, the glia - especially astrocytes and microglia - in the pathophysiology of epilepsy. This review critically evaluates the role of glia-induced hyperexcitability and inflammation in epilepsy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available