Journal
TRENDS IN NEUROSCIENCES
Volume 36, Issue 7, Pages 385-395Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.03.006
Keywords
age-related macular degeneration; retinal pigment epithelium; human embryonic stem cells; induced pluripotent stem cells; transplantation; cellular therapy
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Funding
- The London Project to Cure Blindness
- The Medical Research Council (MRC) UK
- The Californian Institute of Regenerative Medicine (CIRM)
- Fight for Sight UK
- The Lincy Foundation
- The Macular Society
- The National Institute for Health Research
- Medical Research Council [G1000730] Funding Source: researchfish
- MRC [G1000730] Funding Source: UKRI
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Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults and ultimately leads to the death of photoreceptor cells in the macular area of the neural retina. Currently, treatments are only available for patients with the wet form of AMD. In this review, we describe recent approaches to develop cell-based therapies for the treatment of AMD. Recent research has focused on replacing the retinal pigment epithelium (RPE), a monolayer of cells vital to photoreceptor cell health. We discuss the various methods used to differentiate and purify RPE from human embryonic stem cells (HESC), and describe the surgical approaches being used to transplant these cells in existing and forthcoming clinical trials.
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