Journal
TRENDS IN NEUROSCIENCES
Volume 36, Issue 9, Pages 522-534Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.06.002
Keywords
synaptogenesis; neurexin; NGL-3; TrkC; IL1RAPL1; Slitrk
Categories
Funding
- National Institutes of Health [MH070860]
- Canadian Institutes of Health Research [MOP-125967]
- Canada Research Chair awards
- National Alliance for Research on Schizophrenia and Depression (Brain and Behavior Research Fund) Young Investigator award
Ask authors/readers for more resources
Synapse development requires differentiation of presynaptic neurotransmitter release sites and postsynaptic receptive apparatus coordinated by synapse organizing proteins. In addition to the well-characterized neurexins, recent studies identified presynaptic type ha receptor-type protein tyrosine phosphatases (RPTPs) as mediators of presynaptic differentiation and triggers of postsynaptic differentiation, thus extending the roles of RPTPs from axon outgrowth and guidance. Similarly to neurexins, RPTPs exist in multiple isoforms generated by alternative splicing that interact in a splice-selective code with diverse postsynaptic partners. The parallel RPTP and neurexin hub design facilitates synapse self-assembly through cooperation, pairs presynaptic similarity with postsynaptic diversity, and balances excitation with inhibition. Upon mutation of individual genes in neuropsychiatric disorders, imbalance of this synaptic organizing network may contribute to impaired cognitive function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available