Journal
TRENDS IN NEUROSCIENCES
Volume 36, Issue 11, Pages 661-673Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.08.004
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- JSPS (Japan Society for the Promotion of Science) [24220010]
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Body-fluid homeostasis is essential to life, and the concentration of Na+ ([Na+]) and osmolality in plasma and the cerebrospinal fluid (CSF) are continuously monitored in the brain. To maintain a physiological level of Na/osmolality in body fluids, the control of Na and water intake and excretion are of prime importance. Two independent sensing systems for [Na+] and osmolality in circumventricular organs (CVOs) have long been postulated to be involved in the monitoring of body-fluid conditions. In the past decade, several molecules were reported as promising candidates for these sensors - Na-x for the [Na+] sensor and transient receptor potential (TRP) channels for the osmosensor. This review presents a summary of developments in these areas over recent years.
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