Journal
TRENDS IN NEUROSCIENCES
Volume 35, Issue 12, Pages 762-771Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2012.09.007
Keywords
neuronal excitability; voltage-gated ion channels; glutamate receptors; GABA receptors; mitochondrion-associated ER membrane; binding immunoglobulin protein
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Funding
- NIDA, NIH/DHHS
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Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca2+ signaling. In this review, we discuss the current understanding of Sig-1R functions. Based on this, we suggest that the key cellular mechanisms linking Sig-1Rs to neurological disorders involve the translocation of Sig-1Rs from the MAM to other parts of the cell, whereby Sig-1Rs bind and modulate the activities of various ion channels, receptors, or kinases. Thus, Sig-1Rs and their associated ligands may represent new avenues for treating aspects of neurological and psychiatric diseases.
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