Journal
TRENDS IN NEUROSCIENCES
Volume 35, Issue 4, Pages 220-229Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2011.10.007
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Funding
- National Institutes of Health [DC005965, DC007704]
- California Institute of Regenerative Medicine
- Skaggs Institute for Chemical Biology
- Bundy Foundation
- Dorris Neuroscience Center
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Animals use acoustic signals to communicate and to obtain information about their environment. The processing of acoustic signals is initiated at auditory sense organs, where mechanosensory hair cells convert sound-induced vibrations into electrical signals. Although the biophysical principles underlying the mechanotransduction process in hair cells have been characterized in much detail over the past 30 years, the molecular building-blocks of the mechanotransduction machinery have proved to be difficult to determine. We review here recent studies that have both identified some of these molecules and established the mechanisms by which they regulate the activity of the still-elusive mechanotransduction channel.
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