Journal
TRENDS IN NEUROSCIENCES
Volume 34, Issue 1, Pages 1-9Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.10.004
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Funding
- Dana Foundation
- Greenwall Foundation
- NARSAD
- National Institute of Mental Health (NIMH) [K23 MH077869]
- National Institutes of Health
- Northstar, Inc.
- Stanley Medical Research Institute
- Woodruff Foundation
- AvaCat Consulting
- St Jude Medical Neuromodulation
- Oppenheimer Co.
- NATIONAL INSTITUTE OF MENTAL HEALTH [K23MH077869] Funding Source: NIH RePORTER
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The current definition of major depressive disorder (MDD) emerged from efforts to create reliable diagnostic criteria for clinical and research use. However, despite decades of research, the neurobiology of MDD is largely unknown, and treatments are no more effective today than they were 50-70 years ago. Here, we propose that the current conception of depression is misguiding basic and clinical research. Redefinition is necessary and could include a focus on a more narrowly defined set of core symptoms. However, we conclude that depression is better defined as the tendency to enter into, and inability to disengage from, a negative mood state rather than the mood state per se. We also discuss the implications of this revised definition for future clinical and basic research.
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