Journal
TRENDS IN NEUROSCIENCES
Volume 34, Issue 1, Pages 31-40Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.10.001
Keywords
-
Categories
Funding
- Monash University, Australia
- National Health and Medical Research Council of Australia [NHMRC 546131]
Ask authors/readers for more resources
Ghrelin is a peptide hormone produced and secreted in the stomach. Numerous studies over the past decade demonstrate its importance in food intake, body-weight regulation and glucose homeostasis. These effects are driven largely by the high expression of the ghrelin receptor (GHSR1a) in the hypothalamus. However, GHSR1 a is also expressed in numerous extra-hypothalamic neuronal populations, suggesting that ghrelin has physiological functions besides those involved in metabolic functions. In this review, I focus on increasing evidence that ghrelin has important roles in extra-hypothalamic functions, including learning and memory, reward and motivation, anxiety and depression, and neuroprotection. Furthermore, I discuss how the recently demonstrated role of ghrelin in promoting survival during periods of caloric restriction could contribute to its inherent neuroprotective and neuromodulatory properties.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available