Journal
TRENDS IN NEUROSCIENCES
Volume 33, Issue 10, Pages 435-445Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.05.006
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Funding
- National Institutes of Health [R01NS039996-05, R01NS050266-03]
- Howard Hughes Medical Institute
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050266, R01NS039996] Funding Source: NIH RePORTER
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Neuron-type specific gene batteries define the morphological and functional diversity of cell types in the nervous system. Here, we discuss the composition of neuron-type specific gene batteries and illustrate gene regulatory strategies which determine the unique gene expression profiles and molecular composition of individual neuronal cell types from C. elegans to higher vertebrates. Based on principles learned from prokaryotic gene regulation, we argue that neuronal terminal gene batteries are functionally grouped into parallel-acting 'regulons'. The theoretical concepts discussed here provide testable hypotheses for future experimental analysis of the exact gene-regulatory mechanisms employed in the generation of neuronal diversity and identity.
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