Journal
TRENDS IN NEUROSCIENCES
Volume 33, Issue 8, Pages 362-372Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.05.001
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Funding
- CNRS
- Universities of Montpellier 2 and 1
- French National Research Agency (ANR) [05-JCJC-0035, 08-JCJC-0007]
- European Molecular Biology Organization
- Human Frontier Science Program [RGP0023/2008]
- University of Hamburg Medical School
- Deutsche Forschungsgemeinschaft network [KN556/4-1, DFG-FG885]
- Chica and Heinz Schaller Foundation
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In the past decades, a range of post-translational modifications has been discovered on tubulins, the major constituents of microtubules. Pioneering studies have described the occurrence and dynamics of these modifications and provided first insights into their potential functions in regulating the microtubule cytoskeleton. By contrast, several tubulin-modifying enzymes were only discovered in the last few years, and studies on molecular mechanisms and cellular functions of tubulin modifications are just beginning to emerge. This review highlights the roles of tubulin modifications in neurons. Recent studies are also discussed in relation to how the combinatorial use of tubulin modifications could generate a dynamic microtubule code, and how such a code might regulate basic as well as higher-order neuronal functions.
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