Journal
TRENDS IN NEUROSCIENCES
Volume 33, Issue 12, Pages 533-540Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.08.001
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Funding
- Wellcome Trust
- Medical Research Council
- Fondation Neurodis
- MRC [MC_qA137504] Funding Source: UKRI
- Medical Research Council [MC_qA137504] Funding Source: researchfish
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Anatomical and functional studies of the prefrontal cortex (PFC) have identified multiple PFC subregions. We argue that the PFC is involved in cognitive functions exceeding the sum of specific functions attributed to its subregions. These can be revealed either by lesions of the whole PFC, or more specifically by selective disconnection of the PFC from certain types of information (for example, visual) allowing the investigation of PFC function in toto. Recent studies in macaque monkeys using the latter approach lead to a second conclusion: that the PFC, as a whole, could be fundamentally specialized for representing events that are extended in time. The representation of temporally complex events might underlie PFC involvement in general intelligence, decision-making, and executive function.
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