Journal
TRENDS IN NEUROSCIENCES
Volume 33, Issue 9, Pages 415-423Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.06.004
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Funding
- National Institutes of Health [R01-HL70393, R01-NS060706]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL070393] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS060706] Funding Source: NIH RePORTER
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The voltage- and Ca2+-activated K+ (BK) channels are involved in the regulation of neurotransmitter release and neuronal excitability. Structurally, BK channels are homologous to voltage- and ligand-gated K+ channels, having a voltage sensor and pore as the membrane-spanning domain and a cytosolic domain containing metal binding sites. Recently published electron cryomicroscopy (cryo-EM) and X-ray crystallographic structures of the BK channel provided the first glimpse into the assembly of these domains, corroborating the close interactions among these domains during channel gating that have been suggested by functional studies. This review discusses these latest findings and an emerging new understanding about BK channel gating and implications for diseases such as epilepsy, in which mutations in BK channel genes have been associated.
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