Journal
TRENDS IN NEUROSCIENCES
Volume 33, Issue 5, Pages 249-258Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.02.003
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Funding
- E. von Behring Chair for Neuromuscular and Neurodegenerative Disorders
- University of Leuven, the Belgian government
- Thierry Latran Foundation
- Robert Packard Center for ALS Research
- Motor Neurone Disease Association (MNDA) of Great Britain
- Medical Research Council (MRC) (UK)
- ALS Therapy Alliance
- Angel Fund
- Project ALS
- ALS Association
- National Institute for Neurological Disease and Stroke at the National Institutes of Health
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The pathogenic mechanisms of degenerative diseases of the nervous system are not well understood. Recent evidence suggests that proteins with a role in RNA synthesis, processing, function and degradation play a role in the mechanism of degenerative disorders affecting the motor neuron. However, most of these proteins also affect cellular processes other than RNA processing. Furthermore, many of the familial diseases are inherited dominantly, suggesting a gain-of-function as their pathogenic mechanism. This newly gained function could be unrelated to their normal role in the cell. Therefore, here we review some of the recent data linking RNA metabolism and motor neuron disorders, but also critically assess their relevance for our understanding of the mechanism of neurodegeneration.
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