Journal
TRENDS IN NEUROSCIENCES
Volume 32, Issue 8, Pages 451-461Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2009.05.005
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Funding
- National Institutes of Health [P50 AG16574]
- Pacific Alzheimer Research Foundation
- Association for Frontotemporal dementia
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Our understanding of the molecular genetic basis of two common neurodegenerative dementias, Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), has greatly advanced in recent years. Progranulin mutations were identified as a major cause of FTLD and a potential susceptibility factor for other forms of dementia. In addition, through copy-number analyses of previously identified disease genes and the study of microRNA regulation in dementia, new evidence emerged to support the view that subtle variability in the expression of known disease proteins could increase the risk for sporadic forms of dementia. Finally, in late-onset AD populations, the first genome-wide association studies were performed and novel potential AD susceptibility genes reported. These exciting findings provide novel insights into the disease mechanisms underlying dementia and hold promise for the development of potential treatments.
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