Journal
TRENDS IN NEUROSCIENCES
Volume 32, Issue 6, Pages 303-311Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2009.01.008
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Funding
- McKnight Brain Research Foundation
- National Institute of Neurological Disorders and Stroke
- National Institute of Diabetes and Digestive and Kidney Diseases
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS055165] Funding Source: NIH RePORTER
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In addition to radial glial cells of neurohistogenesis, immature astrocytes with stem-cell-like properties cordon off emerging functional patterns in the developing brain. Astrocytes also can be stem cells during adult neurogenesis, and a proposed potency of injury-associated reactive astrocytes has recently been substantiated. Astrocytic cells might additionally be involved in cancer stem cell-associated gliomagenesis. Thus, there are distinguishing roles for stem-cell-like astrocytes during brain development, in neurogenic niches in the adult, during attempted reactive neurogenesis after brain injury or disease and during brain tumorigenesis.
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