Journal
TRENDS IN NEUROSCIENCES
Volume 32, Issue 1, Pages 30-40Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.09.007
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Funding
- EU
- CNISM (Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia)
- Prinses Beatrix Fonds
- Zon-MW
- Neuro-Bsik (Senter)
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Two of the most striking properties of the cerebellum are its control in timing of motor operations and its ability to adapt behavior to new sensorimotor associations. Here, we propose a 'time-window matching' hypothesis for granular layer processing. Our hypothesis states that mossy fiber inputs to the granular layer are transformed into well-timed spike bursts by intrinsic granule cell processing, that feedforward Golgi cell inhibition sets a limit to the duration of such bursts and that these activities are spread over particular fields in the granular layer so as to generate ongoing time-windows for proper control of interacting motor domains. The role of synaptic plasticity would be that of fine-tuning pre-wired circuits favoring activation of specific granule cell groups in relation to particular time windows. This concept has wide implications for processing in the olivo-cerebellar system as a whole.
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