Journal
TRENDS IN NEUROSCIENCES
Volume 32, Issue 1, Pages 56-67Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.09.009
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Funding
- National Institute on Drug Abuse (NIDA) [R01 DA023051.]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007337] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA023051] Funding Source: NIH RePORTER
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Most prior research on the neurobiology of addiction has focused on the role of subcortical systems, such as the amygdala, the ventral striatum and mesolimbic dopamine system, in promoting the motivation to seek drugs, Recent evidence indicates that a largely overlooked structure, the insula, plays a crucial part in conscious urges to take drugs. The insula has been highlighted as a region that integrates interoceptive (i.e. bodily) states into conscious feelings and into decision-making processes that involve uncertain risk and reward. Here, we propose a model in which the processing of the interoceptive effects of drug use by the insula contributes to conscious drug urges and to decision-making processes that precipitate relapse.
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