Journal
TRENDS IN NEUROSCIENCES
Volume 32, Issue 6, Pages 347-358Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2009.02.003
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Funding
- NARSAD
- National Institute of Mental Health Silvio O. Conte Center for Schizophrenia Research
- Lieber Center for Schizophrenia Research
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Schizophrenia is a complex mental disorder that is still characterized by its symptoms rather than by biological markers because we have only a limited knowledge of its underlying molecular basis. In the past two decades, however, technical advances in genetics and brain imaging have provided new insights into the biology of the disease. Based on these advances we are now in a position to develop animal models that can be used to test specific hypotheses of the disease and explore mechanisms of pathogenesis. Here, we consider some of the insights that have emerged from studying in mice the relationship between defined genetic and molecular alterations and the cognitive endophenotypes of schizophrenia.
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