Journal
TRENDS IN NEUROSCIENCES
Volume 31, Issue 10, Pages 538-547Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.07.002
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Funding
- NIH/NINDS [RO1 NS054025]
- Anne and Oscar Lackner Endowed Chair
- Craig H. Neilsen Postdoctoral Fellowship
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS054025] Funding Source: NIH RePORTER
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Paralysis of the diaphragm is a severe consequence of cervical spinal cord injury. This condition can be experimentally modeled by lateralized, high cervical lesions that interrupt descending inspiratory drive to the corresponding phrenic nucleus. Although partial recovery of ipsilateral diaphragm function occurs over time, recent findings show persisting chronic deficits in ventilation and phrenic motoneuron activity. Some evidence suggests, however, that spontaneous recovery can be enhanced by modulating neural pathways to phrenic motoneurons via synaptic circuitries which appear more complex than previously envisioned. The present review highlights these and other recent experimental multidisciplinary findings pertaining to respiratory neuroplasticity in the rat. Translational considerations are also emphasized, with specific attention directed at the clinical and interpretational strengths of different lesion models and outcome measures.
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