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The HPA axis in major depression: classical theories and new developments

Journal

TRENDS IN NEUROSCIENCES
Volume 31, Issue 9, Pages 464-468

Publisher

ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.06.006

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Funding

  1. UK Medical Research Council (MRC)
  2. American Psychiatric Institute for Research and Education (APIRE)
  3. British Academy
  4. Guy's and St. Thomas' Charitable Trust
  5. King's Development Trust
  6. NARSAD Mental Health Research Association
  7. NIHR South London and Maudsley NHS Trust and Institute of Psychiatry (King's College London) Biomedical Research Centre
  8. Biotechnology and Biological Sciences Research Council (BBSRC)
  9. Medical Research Council (MRC)
  10. Wellcome Trust
  11. Neuroendocrinology Charitable Trust (NCT)
  12. Medical Research Council [G108/603] Funding Source: researchfish
  13. MRC [G108/603] Funding Source: UKRI

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Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

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