Journal
TRENDS IN NEUROSCIENCES
Volume 31, Issue 5, Pages 227-233Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.02.003
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Funding
- NICHD NIH HHS [HD01799] Funding Source: Medline
- NIMH NIH HHS [MH66290] Funding Source: Medline
- NINDS NIH HHS [NS38902] Funding Source: Medline
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RNA editing appears to be the major mechanism by which environmental signals overwrite encoded genetic information to modify gene function and regulation, particularly in the brain. We suggest that the predominance of Alu elements in the human genome is the result of their evolutionary co-adaptation as a modular substrate for RNA editing, driven by selection for higher-order cognitive function. We show that RNA editing alters transcripts from loci encoding proteins involved in neural cell identity, maturation and function, as well as in DNA repair, implying a role for RNA editing not only in neural transmission and network plasticity but also in brain development, and suggesting that communication of productive changes back to the genome might constitute the molecular basis of long-term memory and higher-order cognition.
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